Endocrine Abstracts

Objectives: This prospective study aimed at investigating (1) the prevalence of vitamin D deficiency and insufficiency in diabetic adolescents and children in a multi-ethnic cohort, and (2) any association between vitamin D status and ethnic background, glycaemic control (HbA1C), biomarkers of metabolic bone health and lipids.Methodology: Venous blood was drawn from 199 patients with type 1 diabetes (mean age ± SD, 8.2 ± 3.7 years) and 48 patients ...

Thyroid hormones increase foetal and adult metabolic rates, and, in adult tissues, increase mitochondrial biogenesis. Foetal tri-iodothyronine (T3) concentrations rise towards term in preparation for the increased postnatal energy demands but whether they affect mitochondrial development remains unknown. This study examined mitochondrial development in skeletal muscle of thyroid hormone deficient sheep foetuses near term.At 105–110 days (...

Background: Increased frequencies of adrenal tumours and testicular adrenal rest tumours (TART) have been reported in congenital adrenal hyperplasia (CAH).Objective: To investigate the frequency of adrenal abnormalities and TART in an unselected adult population of CAH due to 21-hydroxylase deficiency (21-OH) and whether adrenal and testicular pathology correlate with disease categories, current hormone levels and treatment.Patient...

Multiple endocrine neoplasia type 1 is a rare autosomal-dominant disorder. The most common endocrine tumors are parathyroid tumors, which cause hyperparathyroidism and hypercalcemia. Other tumors of MEN 1 include pituitary tumors for example prolactinomas and enteropancreatic tumors such as gastrinomas, insulinomas, VIPomas, carcinoid tumors. We report a case of a 31 year old male with MEN 1 presenting hypercalcemia with complaints of fatigue and weakness. On further questioni...